Important gabamimetic agent-evokes neurological responses similar to those elicited by -aminobutyric acid (GABA).

For R&D use onlynot for drug household or other uses.

Homotaurine (3-amino-1-propanesulfonic acid (3-APS) or tramiprosate (INN)) is a synthetic organic compound. It is analogous to taurine but with an extra carbon in its chain. It has GABAergic activity apparently by mimicking GABA which is it resembles. Homotaurine was investigated in a Phase III clinical trial as a potential treatment for Alzheimers disease that did not show efficacy in its primary endpoints. In preclinical studies it had been found to bind to soluble amyloid beta and inhibit the formation of neurotoxic aggregates. Homotaurine has also shown anticonvulsant activities reduction in skeletal muscle tonus and hypothermic activity.