Histamine dihydrochloride (INN trade name Ceplene) is a salt of histamine which is used as a drug for the prevention of relapse in patients diagnosed with acute myeloid leukemia (AML). It is an FDA approved active ingredient for topical analgesic use and is available in such products as Australian Dream Cream which is used for the temporary relief of minor aches and pains of muscles and joints associated with arthritis simple backache bruises sprains and strains.

For R&D use onlynot for drug household or other uses.

Histamine is a hydrophilic amine derived from the decarboxylation of histidine by the enzyme L-histidine decarboxylase. Histamine has been shown to play a role in many physiological processes such as gastric secretion neurotransmission immune response vasodialation and inflammation. Additionally studies have reported a role for histamine dihydrochloride with interleukin-2 (IL-2) in treatment of acute myeloid leukemia and in protection against alcohol-induced liver injury in rats.