67-Dihydroxycoumarin

It is present in chicory and in many toxic and medicinal plants in form of glycosides and caffeic acid conjugates. Esculetin-containing preparations used systemically can have an anticoagulant effect and might interact with anticoagulent drugs such as warfarin. This compound is used in some sunscreens but there is evidence that it acts as a photosensitizer for DNA damage. The sodium salt of its methyl-derivative is used in dermatology for the treatment of varicose veins.

For R&D use onlynot for drug household or other uses.

Aesculetin (also known as esculetin 67-dihydroxycoumarin and cichorigenin) is a derivative of coumarin. It is a natural lactone that derives from the intramolecular cyclization of a cinnamic acid derivative. It is a blue fluorescence compound found in plants. Aesculin the glucoside of aesculetin will fluoresce under long wave ultraviolet light (360nm). The hydrolysis of aesculin results in loss of this fluorescence. Aesculetin has the ability to quench the inner fluorescence of bovine serum albumin.Aesculetin can be transformed into scopoletin (7-hydroxy-6-methoxycoumarin) and isoscopoletin (6-hydroxy-7-methoxycoumarin) through incubation with rat liver catechol-O-methyltransferase.