Ethyl 6-Chloronicotinate 97.0%(GC)
97.0%(GC)
Synonym: 6-Chloronicotinic Acid Ethyl Ester
Linear Formula:
C8H8ClNO2
Molecular Weight: 185.61g/mol
CAS Number: 49608-01-7
Properties
| Vapour pressure | 0.0±0.5 mmHg at 25℃ |
| Assay Purity | >97%(GC) |
| Refractive index | 1.525 |
| B pt. | 150 ℃/18 mmHg |
| M pt. | 25℃ |
| Density | 1.245 g/cm3 |
Safety Information
| Hazard Statement(s) | H315-H319 |
| Precautionary Statement | P264-P280-P302 + P352-P337 + P313-P305 + P351 + P338 -P362 + P364-P332 + P313 |
| Symbol |
|
| Signal word | Warning |
| HS Code | 2933399090 |
| Flash point | 110℃ |
| Storage Temp. | 0-10℃ |
| Packaging | Glass Bottle |
Description
Application
Ethyl 6-chloropyridine-3-carboxylate (Ethyl 6-chloronicotinate) may be used in the preparation of ethyl 5-[5-(1H-benzimidazol-2-yl)pyridin-2-yl]ethynylpyridine-2-carboxylate by reacting with 2-[6-(ethynyl)pyridin-3-yl]-1H-benzimidazole under microwave irradiation.
Purpose
For R&D use onlynot for drug household or other uses.
General Description
Ethyl 6-chloropyridine-3-carboxylate (Ethyl-6-chloronicotinate E-6-ClN) undergoes direct amidation on reacting with benzylamine in the presence lanthanum trifluoromethanesulfonate La(OTf)3.[1]The structural and physicochemical properties of E-6-ClN have been investigated based on its spectroscopic data time-dependent density functional theory and density of state diagrams.
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