N-Hydroxysuccinimide can be used in the synthesis ofN-hydroxysuccinimide ester via dehydration reaction in the presence of dicyclohexylcarbodiimide in carboxylic acid. N-Hydroxysuccinimide has been used in the synthesis of intermediates such as 4-[22-bis[(p-tolylsulfonyl)-methyl] acetyl]benzoic acid-NHS ester N-succinimidyl 3-iodobenzoate. It has also been used in a protocol for the surface modification of microchannels of a microfluidic-integrated surface plasmon resonance (SPR) platform for the detection and quantification of bacterial pathogens.

For R&D use onlynot for drug household or other uses.

N-Hydroxysuccinimide (NHS) is an organic compound with the formula C4H5NO3. Being slightly acidic it is an irritant to skin eyes and mucous membranes.