18-Diazabicyclo (5.4.0)undec-7-ene (DBU) PurCert Standard for GC


Linear Formula:  C9H16N2
Molecular Weight:  152.24g/mol
CAS Number: 6674-22-2

Properties

Vapour pressure 5.3 mmHg ( 37.7 ℃)
Water Solubility Completely miscible
Refractive index n20/D 1.522-1.524 (lit.)
B pt. 80-83 ℃/0.6 mmHg (lit.)
M pt. -70℃
Density 1.018 g/mL at 25 ℃ (lit.)

Safety Information

Hazard Statement(s) H290 - H301 - H314 - H412
Precautionary Statement  P234 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
Symbol
Signal word Danger
HS Code 29339930
Flash point 116℃
Storage Temp. Store at Room Temperature.
Storage Class 8
Packaging Glass Bottle
UN Number 3267

Description

Recommended products
1-[3-(Trifluoromethyl)Phenyl]Ethanol 98%

Application
18-Diazabicyclo[5.4.0]undec-7-ene (DBU) may be used as catalyst for carboxylic acid esterification with dimethyl carbonate as base for dehalogenation of halogenated Diels-Alder adducts and the resulting activated 24-dienones were subjected to regio- and stereo-directed Michael additions using Yamamotos reagent (CH3Cu BF3) in a new synthesis of the ABCD ring system of Camptothecin. 18-Diazabicyclo[5.4.0]undec-7-ene may be used as an catalyst for the dissolution and activation of cellulose by a reversible reaction of its hydroxyl groups with carbon dioxide. This dissolved cellulose system can be derivatized to form cellulose mixed esters.

Purpose
For R&D use onlynot for drug household or other uses.

General Description
18-Diazabicyclo[5.4.0]undec-7-ene is a bicyclic amidine base. It is non-nucleophilic sterically hindered tertiary amine base in organic chemistry. It is reported to be superior to amine catalyst in Baylis-Hillman reaction.It promotes the methylation reaction of phenols indoles and benzimidazoles with dimethyl carbonate under mild conditions.