246-Tripropyl-135246-trioxatriphosphinane 246-trioxide

Propylphosphonic anhydride (T3P) can be used In the synthesis of substituted benzofurans as potent DNA gyraseB inhibitors of Mycobacterium tuberculosis. As an acid-amine coupling reagent for the synthesis of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamides which are potent activators of pyruvate kinase M2 (PKM2). As a catalyst in the conversion of ketoximes to amides and aldoximes to nitriles via Beckmann rearrangement.Propylphosphonic anhydride may be used in the following studies As coupling agent for the synthesis of bispyridine-based ligands which are used as bridging linkers in multinuclear platinum anticancer drugs As acid activating agent for the direct synthesis of acid azides from carboxylic acids.[5] One-pot synthesis of 124-oxadiazoles 134-oxadiazoles and 134-thiadiazoles from carboxylic acids.

For R&D use onlynot for drug household or other uses.

Propylphosphonic anhydride (T3P) is a reactiven-propyl phosphonic acid cyclic anhydride.[8]It is a mild and low toxic coupling agent used in peptide synthesis.[6]T3P also acts as a promoter and water scavenger in the Friedlnder annulation reaction.[7]It participates in the conversion of carboxylic acids and amides into nitriles formation of Weinreb amides ester synthesis dehydrations oxidation of alcohols isonitrile synthesis synthesis of alkenes from alcohols and C-C coupling reactions.[8]T3P delivers outstanding advantages over traditional reagents such as broad functional group tolerance low epimerization and water-soluble by-products and hence gives high purity and yield of the product.