Used as a constrained orthogonally protected amino acid analog in solid-phase peptide synthesis (SPPS) and medicinal chemistry for synthesizing peptidomimetics targeting GPCRs enzymes and protease inhibitors.

Provides conformational rigidity through the piperidine ring while maintaining orthogonal reactivity the free amino group for peptide coupling carboxylic acid for esteramide formation and removable Cbz group for nitrogen functionalization.

4-Amino-1-Cbz-piperidine-4-carboxylic acid (CHNO MW 278.30 gmol) is a protected piperidine derivative featuring geminal amino and carboxylic acid groups at position 4 with a carbobenzyloxy (Cbz) protecting group on the piperidine nitrogen typically a white solid with density 1.3 gcm.