6-Chloro-2349-Tetrahydro-1H-Carbazole-1-Carboxamide 98.0%(HPLC)
98.0%(HPLC)
Properties
| Vapour pressure | 0.0±1.4 mmHg at 25℃ |
| Assay Purity | >98%(HPLC) |
| Refractive index | 1.688 |
| B pt. | 531.717℃ at 760 mmHg |
| M pt. | 181℃ |
| Density | 1.389 g/cm3 |
Safety Information
| Hazard Statement(s) | H302-H319 |
| Precautionary Statement | P501-P270-P264-P280-P337 + P313-P305 + P351 + P338-P301 + P312 + P330 |
| Symbol |
|
| Signal word | Warning |
| Flash point | 275.373℃ |
| Storage Temp. | -20℃ |
| Storage Class | 3 |
| Packaging | Glass Bottle |
| UN Number | 1224 |
Description
Application
EX-527 has been used in 1% dimethyl sulfoxide 30% polyethylene glycol-400 and 1% Tween 80 for treating C57BL6 N mice to study its effect on intestinal morphological changes and crypt cell apoptosis as a an inhibitor of sirtuin 1 in treating human cancer lines MCF-7 (Michigan cancer foundation-7) and HCT116 (colon cancer cell line) incubated in Dulbeccos modified Eagles medium to study its effect on mitochondrial ATP (adenosine triphosphate) production.
Purpose
For R&D use onlynot for drug household or other uses.
General Description
Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM.
Documents
| SDS |
| COA |
| Specification |
| Bulk quote order form |