Kenpaullone 97.0%(HPLC)

97.0%(HPLC)


Linear Formula:  C16H11BrN2O
Molecular Weight:  327.18g/mol
CAS Number: 142273-20-9

Properties

Vapour pressure 5.82E-15mmHg at 25℃
Assay Purity >97%(HPLC)
Refractive index 1.73
B pt. 613℃ at 760 mmHg
M pt. >300℃(dec.)
Density 1.596 g/cm3

Safety Information

Hazard Statement(s) H315-H319
Precautionary Statement  P264-P280-P302+P352-P337 + P313-P305 + P351 + P338-P362 + P364-P332 + P313
Symbol
Signal word Warning
Flash point 324.5℃
Storage Temp. 2-8℃
Packaging Glass bottle

Description

Application
Kenpaullone is a potent inhibitor of CDK1cyclin B and GSK-3 with IC50s of 0.4 M and 23 nM and also inhibits CDK2cyclin A CDK2cyclin E and CDK5p25 with IC50s of 0.68 M 7.5 M 0.85 M respectively.

Purpose
For R&D use onlynot for drug household or other uses.

General Description
The paullones are a novel class of kinase inhibitors initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3 inhibitor (IC5023nM).