Methylmalonic acid can be used as a substrate in Esterification reactions by various catalysts. Synthesis of pyrimidinium betaines with formamidine. Synthesis of malonic acid half thioester (MAHT).

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Methylmalonic acid (MMA) (conjugate base methylmalonate) is a dicarboxylic acid that is a C-methylated derivative of malonate. The coenzyme A linked form of methylmalonic acid methylmalonyl-CoA is converted into succinyl-CoA by methylmalonyl-CoA mutase in a reaction that requires vitamin B12 as a cofactor. In this way it enters the Krebs cycle and is thus part of one of the anaplerotic reactions.