(S)-(-)-44-Bis(diphenylphosphino)-33-bi(12-methylenedioxybenzene)

Chiral biaryl bisphosphine catalytic ligand used for Rhodium-catalyzed asymmetric formal olefination or cycloaddition of 13-dicarbonyl compounds with 16-diynes or 16-enynes Stereoselective preparation of homoallylic alcohols via Ir-catalyzed stereoselective transfer hydrogenative crotylation of an allylic acetate with alcohols or aldehydes Regio- and stereoselective preparation of axially chiral arylnaphthalene derivatives via rhodium-catalyzed [222] cycloaddition of diynes with naphthalenepropynoic acid derivatives Diastereo- and enantioselective hydrogenation of -amino--keto ester hydrochlorides catalyzed by an iridium complex Preparation of dihydroisoquinolinones via nickel-catalyzed denitrogenative annulation of benzotriazinones with 13-dienes and alkenes

SEGPHOS is a chiral ligand developed by Takasago that is used in asymmetric synthesis. It was developed after BINAP and was investigated since it has a narrower dihedral angle between the aromatic faces. This was predicted and then confirmed to increase the enantioselectivity and activity of metal complexes of SEGPHOS.