4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one PurCert Secondary Working Standard [Includes all characterization data]

CRM


Linear Formula:  C5H5ClO3
Molecular Weight:  148.54 g/mol
CAS Number: 80841-78-7

Properties

Assay Purity >=95 %
Refractive index n20/D 1.4760-1.4820
B pt. >90°C
Density 1.362 g/cm3
Form Solid

Safety Information

Hazard Statement(s) H302, H315, H319, H335
Precautionary Statement  P261, P305, P338, P351
GHS Pictogram
Signal word Warning
HS Code 29329990
Flash point 129 °C
Storage Temp. Room Temperature
Storage Class 10 - Combustible liquids

Description

Application
It is widely used as a pharmaceutical intermediate and building block in the synthesis of medoxomil ester prodrugs and other active pharmaceutical ingredients.

Purpose
Its primary purpose is to introduce the medoxomil (cyclic carbonate) moiety into drug molecules to improve oral bioavailability and pharmacokinetic properties.

General Description
4-(Chloromethyl)-5-methyl-13-dioxol-2-one is a cyclic carbonate compound (CAS 80841-78-7 molecular formula C5H5ClO3) containing a reactive chloromethyl group that readily undergoes nucleophilic substitution reactions.