A 2.0 M ammonia solution in isopropanol is commonly used as a basic reagent and deprotection reagent in organic and synthetic chemistry including certain solid-phase synthesis processes.

Its purpose is to provide a controlled source of ammonia under basic conditions which can be used to remove suitable protecting groups cleave certain labile linkages or promote specific base-mediated transformations.

The reagent is a solution containing ammonia at a concentration of 2.0 molL in isopropanol (IPA). Ammonia provides the basic and nucleophilic component while isopropanol acts as the organic solvent providing a suitable medium for reactions requiring an anhydrous or predominantly organic environment.