It treats atopic dermatitis eczema acute otitis externa in dogs allergic skin conditions and corticosteroid-responsive dermatoses in veterinary and human medicine available as cream ointment or solution.

Its primary purpose is potent topical anti-inflammatory action via glucocorticoid receptor binding suppressing cytokines and prostaglandins while rapid ester hydrolysis minimizes HPA axis suppression.

Hydrocortisone aceponate (C26H36O7) is a diester derivative of hydrocortisone featuring aceponate (1-acetoxypropionyloxy) groups at both C17 and C21 positions appearing as a white to almost white crystalline powder with molecular weight 452.57 gmol designed for topical use with reduced systemic bioavailability.