It is used in high-performance liquid chromatography (HPLC) as an ion-pairing reagent to improve the separation of polar and charged molecules. It also finds use in organic synthesis and biochemical studies.

The purpose of sodium butane-1-sulfonate is to enhance the retention and resolution of ionic or polar compounds in chromatographic analyses and to act as a stable sulfonate donor in various chemical reactions.

Sodium butane-1-sulfonate is a white water-soluble crystalline salt with the chemical formula CHSONa. It is an anionic compound commonly used as a sulfonate source in chemical and analytical applications.