Trifluoroacetic Acid for spectroscopy

Others


Synonym:  TFA
Linear Formula:  CF3COOH
Molecular Weight:  114.02 g/mol
CAS Number: 76-05-1

Properties

Vapour pressure 97.5 mmHg ( 20 °C)
Water Solubility 10,000 g/l
Assay Purity >=99.8%
Refractive index n20/D 1.3 (lit.)
B pt. 72.4 °C (lit.)
M pt. -15.4°C(lit.)
Density 1.489 g/mL at 20°C (lit.)
Form Liquid

Safety Information

Hazard Statement(s) H314,H332,H412
Precautionary Statement  P261 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
GHS Pictogram
Signal word Danger
HS Code 29159099
Storage Temp. Room Temperature
Storage Class 8A - Combustible corrosive hazardous materials
UN Number 2699

Description

Application
In spectroscopy trifluoroacetic acid is mainly used as a solvent or additive to improve sample solubility and stability. In techniques like NMR and HPLC-related detection it helps in protonating compounds sharpening peaks and improving resolution. Its simple structure also minimizes interference in spectra making it useful for accurate analysis of organic molecules.

Purpose
Its primary purpose is to provide a highly acidic medium for reactions. It is used to remove protecting groups in peptide synthesis act as a catalyst in organic reactions and improve the solubility of compounds. It also helps in analytical techniques by

General Description
Trifluoroacetic acid is known for its high acidity stability and ability to dissolve a wide range of organic compounds. It is also relatively non-oxidizing and can act as both a solvent and a reagent in chemical reactions. Due to its volatility it can be easily removed from reaction mixtures by evaporation.