23-Bis(4-Hydroxyphenyl)Propionitrile 98.0%(GC)
98.0%(GC)
Synonym: Diarylpropionitrile
Linear Formula:
C15H13NO2
Molecular Weight: 239.27g/mol
CAS Number: 1428-67-7
Properties
| Vapour pressure | 1.08E-08mmHg at 25℃ |
| Assay Purity | >98%(GC) |
| Refractive index | 1.639 |
| B pt. | 449.4℃ at 760 mmHg |
| M pt. | 203℃ |
| Density | 1.256 g/cm3 |
Safety Information
| Hazard Statement(s) | H302+H312+H332-H315-H319 |
| Precautionary Statement | P501-P261-P270-P271-P264-P280-P302+P352-P337 + P313-P305 + P351 + P338-P362 + P364-P332 + P313-P301 + P312 + P330-P304 + P340 + P312 |
| Symbol |
|
| Signal word | Warning |
| Flash point | 225.6℃ |
| Storage Temp. | Store at Room temperature. |
| Storage Class | 9 |
| Packaging | Glass bottle |
| UN Number | 3077 |
Description
Application
Diarylpropionitrile (DPN) also known as 23-bis(p-hydroxyphenyl)propionitrile (23-BHPPN) is a synthetic non-steroidal and highly selective agonist of ER (IC50 15 nM) that is used widely in scientific research to study the function of this receptor. It is 70-fold more selective for ER over ER and has 100-fold lower affinity for GPER (GPR30) relative to estradiol.
Purpose
For R&D use onlynot for drug household or other uses.
General Description
Diarylpropionitrile(DPN) is a non-steroidal estrogen receptor (ER ) selective ligand.IC50 valueTarget ER ligandin vitro Pre-treatment with 1-100 nM DPN significantly decreased neuronal cell death by increasing cell viability through a significant attenuation in the reactive oxygen species level downregulation of pro-apoptotic activated caspase-3 and Bax and upregulation of anti-apoptotic Bcl-2 thereby mitigating apoptotic morphological alterations.
Documents
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| Specification |
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