nitro-7 indazole

For R&D use onlynot for drug household or other uses.

7-Nitroindazole or 7-NI is a heterocyclic small molecule containing an indazole ring that has been nitrated at the 7 position. Nitroindazole acts as a selective inhibitor for neuronal nitric oxide synthase a hemoprotein enzyme that in neuronal tissue converts arginine to citrulline and nitric oxide (NO). Nitric oxide can diffuse through the plasma membrane into neighbouring cells allowing cell signalling so nitroindazole indirectly inhibits this signalling process. Other inhibitors exist such as 3-bromo-7-nitroindazole which is more potent but less specific or NPA (N-propyl-L-arginine) which acts on a different site.