Glycocyamine is a direct precursor of creatine and is used as a supplement. However the metabolism of creatine from glycocyamine in the liver causes a depletion of methyl groups. This causes homocysteine levels to rise which has been shown to produce cardiovascular and skeletal problems.

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Glycocyamine (or guanidinoacetate) is a metabolite of glycine in which the amino group has been converted into a guanidine. 2-Guanidinoacetic acid a precursor of creatine is a replacement of dietary arginine and could support overall energy homeostasis of the bird.