Kynurenic Acid Hydrate 98.0%(HPLC)

98.0%(HPLC)


Linear Formula:  C10H7NO3·xH2O
Molecular Weight:  189.17g/mol
CAS Number: 492-27-3

Properties

Vapour pressure 1.31E-11mmHg at 25℃
Assay Purity >98%(HPLC)
Refractive index 1.639
B pt. 358.4℃ at 760 mmHg
M pt. 275 ℃(dec.)(lit.)
Density 1.429 g/cm3

Safety Information

Hazard Statement(s) H315-H319
Precautionary Statement  P264-P280-P302 + P352-P337 + P313-P305 + P351 + P338 -P362 + P364-P332 + P313
Symbol
Signal word Warning
Flash point 170.5℃
Storage Temp. Store at room temperature
Storage Class 3
Packaging Poly Bottle
UN Number 2456

Description

Application
Kynurenic acid has been used as a constituent in dissection saline solution for embryonic cerebral cortical cells[7]and human primary astrocytes.[8]It has also been used as a medium supplement for murine intestinal epithelial cell line MODE-K[9]and induced pluripotent stem cell (iPSC)-derived neurons cells.

Purpose
For R&D use onlynot for drug household or other uses.

General Description
Kynurenic acid (KYNA or KYN) is a product of the normal metabolism of amino acid L-tryptophan. It has been shown that kynurenic acid possesses neuroactive activity. It acts as an antiexcitotoxic and anticonvulsant most likely through acting as an antagonist at excitatory amino acid receptors. Because of this activity it may influence important neurophysiological and neuropathological processes. As a result kynurenic acid has been considered for use in therapy in certain neurobiological disorders. Conversely increased levels of kynurenic acid have also been linked to certain pathological conditions.