Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

For R&D use onlynot for drug household or other uses.

Guanidinium chloride or guanidine hydrochloride usually abbreviated GdmCl and sometimes GndCl or GuHCl is the hydrochloride salt of guanidine.