2-Amino-5-[(5-Nitro-2-Thiazolyl)Thio]-134-Thiadiazole 96.0%(HPLC)
96.0%(HPLC)
Properties
| Assay Purity | >96%(HPLC) |
| Refractive index | 1.793 |
| B pt. | 549.841℃ at 760 mmHg |
| M pt. | 160℃(dec.) |
| Density | 1.888g/cm3 |
Safety Information
| Hazard Statement(s) | H319-H315 |
| Precautionary Statement | P264-P302 -P352- P280-P337 + P313-P305 + P351 + P338-P362 + P364-P332 |
| Symbol |
|
| Signal word | Warning |
| Flash point | 286.334℃ |
| Storage Temp. | Store at <0℃ |
| Storage Class | 5.1 |
| Packaging | Glass bottle |
| UN Number | 2465 |
Description
Recommended products
5-(5-nitrothiazol-2-ylthio)-134-thiadiazol-2-amine
Purpose
For R&D use onlynot for drug household or other uses.
General Description
A cell-permeable non-peptidyl thiazolyl-thiadiazole alternative to pepJIP1 (TI-JIP1153-163) and TAT-pepJIP1 (Cat. Nos. 420133 & 420134 respectively) as a JIP-docking site-targeting (IC50 239 nM against pepJIP1 binding to JNK1) and substrate-competitive JNK inhibitor (IC50 700 nM against ATF2 phosphorylation by JNK1) while exhibiting little activity (IC5050 M) toward p38 Akt furin or lethal factor. Shown to inhibit the phosphorylation of overexpressed GFP-c-Jun in HeLa cultures upon TNF- stimulation (IC50 6.23 M)in vitroand restore insulin sensitivity in a murine of type-2 diabetes model (25 mgkg i.p.)in vivo. Biostability analysis with rat liver microsome preparations results in a compound half-life of 27 min at 37.5&8451.
Documents
| SDS |
| COA |
| Specification |
| Bulk quote order form |