78-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one

78-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in miceand to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).

For R&D use onlynot for drug household or other uses.

78-Dihydroxyflavone (78-DHF) is a naturally-occurring flavone found in Godmania aesculifolia Tridax procumbens and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the TrkB receptor (Kd 320 nM) the main signaling receptor of brain-derived neurotrophic factor (BDNF). 78-DHF is both orally-bioavailable and able to penetrate the blood-brain-barrier. 78-DHF has demonstrated remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders including depression Alzheimers disease cognitive deficits in schizophrenia Parkinsons disease Huntingtons disease amyotrophic lateral sclerosis traumatic brain injury cerebral ischemia fragile X syndrome and Rett syndrome. 78-DHF also shows efficacy in animal models of age-associated cognitive impairment and enhances memory consolidation and emotional learning in healthy rodents. In addition 78-DHF possesses powerful antioxidant activity independent of its actions on the TrkB receptor and protects against glutamate-induced excitotoxicity 6-hydroxydopamine-induced dopaminergic neurotoxicity and oxidative stress-induced genotoxicity. It was also found to block methamphetamine-induced dopaminergic neurotoxicity an effect which in contrast to the preceding was found to be TrkB-dependent.