444-Trifluoroacetoacetic Acid Ethyl Ester

Ethyl 444-trifluoroacetoacetate (ETFAA) is a general reagent to synthesize enantiopure trifluoromethyl-functionalized products.Applications include Synthesis of (S)- and (R)--trifluoromethyl-aspartic acid and - trifluoromethyl-serine from chiral CF3-oxazolidines which is derived from ETFAA. Enantiopure synthesis of trifluoromethyl--amino acid derivatives. Synthesis of (2R)-2-trifluoromethyl-2-carboxyazetidine (R)- and (S)-trifluoromethylhomoserines from oxazolidine intermediate obtained by condensing (R)-phenylglycinol with ETFAA.

For R&D use onlynot for drug household or other uses.