20 % Diethylamine in Acetonitrile PurOligo
PurOligo
Linear Formula:
Diethylamine: C4H11N, Acetonitrile: C2H3N
Molecular Weight: Diethylamine: 73.14 g/mol, Acetonitrile: 41.053 g/mol
CAS Number: Diethylamine: 109-89-7, Acetonitrile: 75-05-8
Properties
| Vapour pressure | No data available |
| Water Solubility | Soluble |
| Autoignition temp. | No data available |
| Explosion limit | Upper explosion limit: 10.1 %(V) Lower explosion limit: 1.8 %(V) |
| Assay Purity | Acetonitrile: >99.9 % , Diethylamine: >99.9 % |
| Refractive index | 1.351-1.353 |
| B pt. | 86°C |
| M pt. | Nodataavailable |
| Density | No data available |
| Form | Liquid |
Safety Information
| Hazard Statement(s) | H225-H302+H312+H332-H314-H335 |
| Precautionary Statement | P210-P280-P303+P361+P353-P304+P340-P310-P305+P351+P338 |
| GHS Pictogram |
|
| Signal word | Danger |
| Flash point | 2°C |
| Storage Temp. | Room Temperature |
| Storage Class | 3 - Flammable liquids |
| UN Number | 2924 |
Description
Other Notes
Alkylation of the N3-position of thymidine by acrylnitrile which is liberated during -elimination of the cyanoethyl group from the phosphates is a well-known side reaction during simultaneous cleavage of the protecting groups and the oligonucleotide from the support.This side reaction can be avoided by use of diethylamine or t-butylamine in acetonitrile for the -elimination. The oligonucleotide is subsequently cleaved from the support using any standard cleavage conditions.
Application
Cleavage reagent for nucleic acid synthesis.
Documents
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