Incorporated into synthetic peptides to prevent methionine oxidation artifacts during Fmoc-SPPS produces uniform Met(O)-peptides that purify easily before selective reduction to native Met.

Methionine sulfoxide protection strategy ensures high purity final peptides by avoiding variable oxidation states selectively reduced post-synthesis using DTT TCEP or ascorbate.

Fmoc-Met(O)-OH (CHNOS MW 387.45 gmol CAS 76265-70-8) is N-Fmoc protected L-methionine sulfoxide a white powder used in solid-phase peptide synthesis.