Doxorubicin Hydrochloride Purcert Secondary Reference Standard (CRM) [Includes all characterization data]
PurCert
Synonym: Hydroxydaunorubicin Hydrochloride
Linear Formula:
C27H29NO11
Molecular Weight: 579.98 g/mol
CAS Number: 25316-40-9
Properties
| Vapour pressure | PurCert |
| M pt. | 216°C(dec.)(lit.) |
| Form | Solid |
Safety Information
| Hazard Statement(s) | H302,H340,H350,H360FD |
| Precautionary Statement | P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313 |
| GHS Pictogram |
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| Signal word | Danger |
| HS Code | 29419090 |
| Storage Temp. | 2-8°C |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
Description
Application
It is administered intravenously to treat a wide range of cancers including breast cancer leukemia lymphomas sarcomas ovarian carcinoma and gastric cancer often in combination therapies like AC (Adriamycin cyclophosphamide) or CHOP regimens.
Purpose
Doxorubicin exerts cytotoxicity through DNA intercalation that inhibits topoisomerase II generates free radicals damaging DNA and membranes and induces apoptosis with dose-limited cardiotoxicity as the primary adverse effect.
General Description
Doxorubicin hydrochloride is the hydrochloride salt of an anthracycline antitumor antibiotic with the molecular formula CHClNO (MW 579.99 gmol CAS 25316-40-9) featuring a planar tetracyclic ring system with amino sugar daunosamine appearing as an orange-red lyophilized powder that is stable at room temperature when protected from light.
Documents
| SDS | |
| COA | |
| Specification | |
| Bulk quote order form | |
| Sample COA |