It is used topically (cream ointment solution milk) for corticosteroid-responsive dermatoses including atopic dermatitis allergic contact eczema psoriasis and facialscalp eczema suitable for children and once-daily application.

Its primary purpose is reducing skin inflammation via glucocorticoid receptor agonism suppressing arachidonic acid metabolites (prostaglandins leukotrienes) with high lipophilicity and rapid metabolism minimizing HPA axis suppression.

Methylprednisolone aceponate (CHO) is a potent topical glucocorticoid featuring a diester derivative of methylprednisolone with acetate at C21 and propionate at C17 designed for enhanced skin penetration and reduced systemic absorption appearing as a white to yellowish crystalline powder with molecular weight 472.58 gmol