Sodium citrate tribasic dihydrate can be used as a catalyst to synthesize Fused O- and N-heterocyclic derivatives via multicomponent Knoevenagel-cyclocondensation of isatinaldehyde acenaphthylene-12-dione malononitrile and various CH activated acids. Chromeno[3456]pyrano[23-d]pyrimidines by the condensation reaction of 4-hydroxycoumarin aromatic aldehydes and barbituric acidthiobarbituric acid. It can also be used as A reducing agent to synthesize metal nanoparticles via sol-gel method using corresponding metal salt precursors. A controlling agent in the synthesis of single-crystal of coordination polymer [Co(H2O)2Ni(CN)4 4H2O].

Sodium citrate tribasic dihydrate is a white crystalline powder commonly used in food pharmaceutical and laboratory applications. Chemically it is the sodium salt of citric acid with two molecules of water (dihydrate) and it has the formula NaCHO2HO. It is highly soluble in water and has a mildly salty slightly tart taste. This compound acts as a buffering agent emulsifier and preservative helping to control pH and stabilize formulations. In medicine it is often used as an anticoagulant to prevent blood clotting while in food products it enhances flavor and improves texture especially in processed cheese and beverages.