Dimethyloxaloylglycine 97.0%(GC)

97.0%(GC)


Linear Formula:  C6H9NO5
Molecular Weight:  175.14g/mol
CAS Number: 89464-63-1

Properties

Assay Purity >97%(GC)
Refractive index 1.44
B pt. 182 ℃/12 mmHg
M pt. 51℃
Density 1.247g/cm3

Safety Information

Hazard Statement(s) H302
Precautionary Statement  P301 + P312 + P330
Symbol
Signal word Warning
HS Code 2924199090
Storage Temp. Store at room temperature..
Packaging Glass Bottle

Description

Recommended products
9-(4-Biphenylyl)-3-Bromocarbazole 98.0%(GC)

Application
DMOG has been used in hypoxia-inducible factor (HIF) activity assay to examine its effects on the degradation of HIF-1 and renal regeneration in DMOG preconditioning of adipose tissues as vehicle control for the primary liquid culture of CD34 cells.

Purpose
For R&D use onlynot for drug household or other uses.

General Description
DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models (1nM). DMOG also inhibits FIH (factor inhibiting HIF) an asparaginyl hydroxylase which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mgKg).