(S)-()-Rolipram 98.0%(HPLC)

98.0%(HPLC)


Properties

Vapour pressure 0.0±1.2 mmHg at 25℃
Assay Purity >98%(HPLC)
Refractive index 1.552
B pt. 472.7±45.0 ℃ at 760 mmHg
M pt. 134℃
Density 1.2±0.1 g/cm3

Safety Information

Symbol
HS Code 2933790090
Flash point 239.7±28.7℃
Storage Temp. Store at room temperature..
Storage Class 3
Packaging Glass Bottle
UN Number 1987

Description

Recommended products
(S)-4-Benzyloxy-13-Butanediol 96.0%(GC)

Purpose
For R&D use onlynot for drug household or other uses.

General Description
(S)-()-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent less potent than its R enantiomer.Target PDE4B PDE4DRolipram a selective inhibitor of the cyclic AMP-specific phosphodiesterase (PDE IV). Rolipram did not inhibit 5-lipoxygenase activity but did inhibit human monocyte production of leukotriene B4 (LTB4 IC50 3.5 microM). Rolipram inhibited arachidonic acid-induced inflammation in the mouse while the low Km-cyclic-GMP PDE inhibitor. Rolipram had a modest effect on LTB4 production in the mouse but markedly reduced LTB4-induced PMN infiltration